Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Bmp2  bone morphogenetic protein 2   (Synonyms: Bmp2a)
Results	Reference
1*	J:74162 Abdelwahid E, Rice D, Pelliniemi LJ, Jokinen E, Overlapping and differential localization of Bmp-2, Bmp-4, Msx-2 and apoptosis in the endocardial cushion and adjacent tissues of the developing mouse heart. Cell Tissue Res. 2001 Jul;305(1):67-78
1*	J:92174 Aberg T, Wang XP, Kim JH, Yamashiro T, Bei M, Rice R, Ryoo HM, Thesleff I, Runx2 mediates FGF signaling from epithelium to mesenchyme during tooth morphogenesis. Dev Biol. 2004 Jun 1;270(1):76-93
1	J:44411 Aberg T, Wozney J, Thesleff I, Expression patterns of bone morphogenetic proteins (Bmps) in the developing mouse tooth suggest roles in morphogenesis and cell differentiation. Dev Dyn. 1997 Dec;210(4):383-96
1	J:79879 Akiyama H, Chaboissier MC, Martin JF, Schedl A, De Crombrugghe B, The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. Genes Dev. 2002 Nov 1;16(21):2813-28
1	J:170583 Baek JA, Lan Y, Liu H, Maltby KM, Mishina Y, Jiang R, Bmpr1a signaling plays critical roles in palatal shelf growth and palatal bone formation. Dev Biol. 2011 Feb 15;350(2):520-31
1*	J:29484 Bennett JH, Hunt P, Thorogood P, Bone morphogenetic protein-2 and -4 expression during murine orofacial development. Arch Oral Biol. 1995 Sep;40(9):847-54
1*	J:29671 Bitgood MJ, McMahon AP, Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo. Dev Biol. 1995 Nov;172(1):126-38
1	J:274818 Chen Y, Wang Z, Chen Y, Zhang Y, Conditional deletion of Bmp2 in cranial neural crest cells recapitulates Pierre Robin sequence in mice. Cell Tissue Res. 2019 May;376(2):199-210
1*	J:39018 Dudley AT, Robertson EJ, Overlapping expression domains of bone morphogenetic protein family members potentially account for limited tissue defects in BMP7 deficient embryos. Dev Dyn. 1997 Mar;208(3):349-62
1*	J:41080 Furuta Y, Piston DW, Hogan BL, Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development. Development. 1997 Jun;124(11):2203-12
1*	J:134348 Gu S, Wei N, Yu X, Jiang Y, Fei J, Chen Y, Mice with an anterior cleft of the palate survive neonatal lethality. Dev Dyn. 2008 May;237(5):1509-16
1	J:165723 He F, Xiong W, Wang Y, Matsui M, Yu X, Chai Y, Klingensmith J, Chen Y, Modulation of BMP signaling by Noggin is required for the maintenance of palatal epithelial integrity during palatogenesis. Dev Biol. 2010 Nov 1;347(1):109-21
1	J:144627 He F, Xiong W, Yu X, Espinoza-Lewis R, Liu C, Gu S, Nishita M, Suzuki K, Yamada G, Minami Y, Chen Y, Wnt5a regulates directional cell migration and cell proliferation via Ror2-mediated noncanonical pathway in mammalian palate development. Development. 2008 Dec;135(23):3871-9
1*	J:136831 Ho AM, Marker PC, Peng H, Quintero AJ, Kingsley DM, Huard J, Dominant negative Bmp5 mutation reveals key role of BMPs in skeletal response to mechanical stimulation. BMC Dev Biol. 2008;8:35
1*	J:54206 Jung HS, Oropeza V, Thesleff I, Shh, Bmp-2, Bmp-4 and Fgf-8 are associated with initiation and patterning of mouse tongue papillae. Mech Dev. 1999 Mar;81(1-2):179-82
1	J:51084 Keranen SV, Aberg T, Kettunen P, Thesleff I, Jernvall J, Association of developmental regulatory genes with the development of different molar tooth shapes in two species of rodents. Dev Genes Evol. 1998 Nov;208(9):477-86
1	J:56749 Keranen SV, Kettunen P, Aberg T, Thesleff I, Jernvall J, Gene expression patterns associated with suppression of odontogenesis in mouse and vole diastema regions. Dev Genes Evol. 1999 Aug;209(8):495-506
1*	J:116785 Kettunen P, Nie X, Kvinnsland IH, Luukko K, Histological development and dynamic expression of Bmp2-6 mRNAs in the embryonic and postnatal mouse cranial base. Anat Rec A Discov Mol Cell Evol Biol. 2006 Dec;288(12):1250-8
1	J:147277 Lan Y, Jiang R, Sonic hedgehog signaling regulates reciprocal epithelial-mesenchymal interactions controlling palatal outgrowth. Development. 2009 Apr;136(8):1387-96
1	J:245974 Li J, Cui Y, Xu J, Wang Q, Yang X, Li Y, Zhang X, Qiu M, Zhang Z, Zhang Z, Suppressor of Fused restraint of Hedgehog activity level is critical for osteogenic proliferation and differentiation during calvarial bone development. J Biol Chem. 2017 Sep 22;292(38):15814-15825
1	J:57673 Lin CR, Kioussi C, O'Connell S, Briata P, Szeto D, Liu F, Izpisua-Belmonte JC, Rosenfeld MG, Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis. Nature. 1999 Sep 16;401(6750):279-82
1*	J:217173 Lockhart MM, Boukens BJ, Phelps AL, Brown CL, Toomer KA, Burns TA, Mukherjee RD, Norris RA, Trusk TC, van den Hoff MJ, Wessels A, Alk3 mediated Bmp signaling controls the contribution of epicardially derived cells to the tissues of the atrioventricular junction. Dev Biol. 2014 Dec 1;396(1):8-18
1	J:63337 Lu H, Jin Y, Tipoe GL, Alteration in the expression of bone morphogenetic protein-2,3,4,5 mRNA during pathogenesis of cleft palate in BALB/c mice. Arch Oral Biol. 2000 Feb;45(2):133-40
1*	J:15320 Lyons KM, Pelton RW, Hogan BL, Patterns of expression of murine Vgr-1 and BMP-2a RNA suggest that transforming growth factor-beta-like genes coordinately regulate aspects of embryonic development. Genes Dev. 1989 Nov;3(11):1657-68
1*	J:32952 Lyons KM, Pelton RW, Hogan BL, Organogenesis and pattern formation in the mouse: RNA distribution patterns suggest a role for bone morphogenetic protein-2A (BMP-2A). Development. 1990 Aug;109(4):833-44
1	J:186306 Morello R, Bertin TK, Schlaubitz S, Shaw CA, Kakuru S, Munivez E, Hermanns P, Chen Y, Zabel B, Lee B, Brachy-syndactyly caused by loss of Sfrp2 function. J Cell Physiol. 2008 Oct;217(1):127-37
1*	J:187968 Okano J, Kimura W, Papaioannou VE, Miura N, Yamada G, Shiota K, Sakai Y, The regulation of endogenous retinoic acid level through CYP26B1 is required for elevation of palatal shelves. Dev Dyn. 2012 Nov;241(11):1744-56
1*	J:77812 Perriton CL, Powles N, Chiang C, Maconochie MK, Cohn MJ, Sonic hedgehog signaling from the urethral epithelium controls external genital development. Dev Biol. 2002 Jul 1;247(1):26-46
1	J:162170 Roybal PG, Wu NL, Sun J, Ting MC, Schafer CA, Maxson RE, Inactivation of Msx1 and Msx2 in neural crest reveals an unexpected role in suppressing heterotopic bone formation in the head. Dev Biol. 2010 Jul 1;343(1-2):28-39
1	J:198279 Song Z, Liu C, Iwata J, Gu S, Suzuki A, Sun C, He W, Shu R, Li L, Chai Y, Chen Y, Mice with Tak1 deficiency in neural crest lineage exhibit cleft palate associated with abnormal tongue development. J Biol Chem. 2013 Apr 12;288(15):10440-50
1	J:194058 Sun J, Ishii M, Ting MC, Maxson R, Foxc1 controls the growth of the murine frontal bone rudiment by direct regulation of a Bmp response threshold of Msx2. Development. 2013 Mar;140(5):1034-44
1	J:245879 Tischfield MA, Robson CD, Gilette NM, Chim SM, Sofela FA, DeLisle MM, Gelber A, Barry BJ, MacKinnon S, Dagi LR, Nathans J, Engle EC, Cerebral Vein Malformations Result from Loss of Twist1 Expression and BMP Signaling from Skull Progenitor Cells and Dura. Dev Cell. 2017 Sep 11;42(5):445-461.e5
1*	J:28253 Tureckova J, Sahlberg C, Aberg T, Ruch JV, Thesleff I, Peterkova R, Comparison of expression of the msx-1, msx-2, BMP-2 and BMP-4 genes in the mouse upper diastemal and molar tooth primordia. Int J Dev Biol. 1995 Jun;39(3):459-68
1	J:200760 Wang Y, Zheng Y, Chen D, Chen Y, Enhanced BMP signaling prevents degeneration and leads to endochondral ossification of Meckel's cartilage in mice. Dev Biol. 2013 Sep 15;381(2):301-11
1*	J:149232 Xiong W, He F, Morikawa Y, Yu X, Zhang Z, Lan Y, Jiang R, Cserjesi P, Chen Y, Hand2 is required in the epithelium for palatogenesis in mice. Dev Biol. 2009 Jun 1;330(1):131-41
1*	J:22224 Yamaji N, Celeste AJ, Thies RS, Song JJ, Bernier SM, Goltzman D, Lyons KM, Nove J, Rosen V, Wozney JM, A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4. Biochem Biophys Res Commun. 1994 Dec 30;205(3):1944-51
1*	J:78220 Zhang Z, Song Y, Zhao X, Zhang X, Fermin C, Chen Y, Rescue of cleft palate in Msx1-deficient mice by transgenic Bmp4 reveals a network of BMP and Shh signaling in the regulation of mammalian palatogenesis. Development. 2002 Sep;129(17):4135-46
1	J:154920 Zirzow S, Ludtke TH, Brons JF, Petry M, Christoffels VM, Kispert A, Expression and requirement of T-box transcription factors Tbx2 and Tbx3 during secondary palate development in the mouse. Dev Biol. 2009 Dec 15;336(2):145-55